1wz3
From Proteopedia
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| - | [[Image:1wz3.gif|left|200px]] | + | [[Image:1wz3.gif|left|200px]] |
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| - | '''The crystal structure of plant ATG12''' | + | {{Structure |
| + | |PDB= 1wz3 |SIZE=350|CAPTION= <scene name='initialview01'>1wz3</scene>, resolution 1.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''The crystal structure of plant ATG12''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1WZ3 is a [ | + | 1WZ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ3 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of plant ATG12 and its biological implication in autophagy., Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F, Autophagy. 2005 Jul;1(2):119-26. Epub 2005 Jul 23. PMID:[http:// | + | The crystal structure of plant ATG12 and its biological implication in autophagy., Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F, Autophagy. 2005 Jul;1(2):119-26. Epub 2005 Jul 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16874047 16874047] |
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ubiquitin-fold]] | [[Category: ubiquitin-fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:03:18 2008'' |
Revision as of 13:03, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of plant ATG12
Overview
Atg12 is a post-translational modifier that is activated and conjugated to its single target, Atg5, by a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate is essential for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. Here, we demonstrate that the Atg12 conjugation system exists in Arabidopsis and is essential for plant autophagy as well as in yeast and mammals. We also report the crystal structure of Arabidopsis thaliana (At) ATG12 at 1.8 A resolution. Despite no obvious sequence homology with ubiquitin, the structure of AtATG12 shows a ubiquitin fold strikingly similar to those of mammalian homologs of Atg8, the other ubiquitin-like modifier essential for autophagy, which is conjugated to phosphatidylethanolamine. Two types of hydrophobic patches are present on the surface of AtATG12: one is conserved in both Atg12 and Atg8 orthologs, while the other is unique to Atg12 orthologs. Considering that they share Atg7 as an E1-like enzyme, we suggest that the first hydrophobic patch is responsible for the conjugation reaction, while the latter is involved in Atg12-specific functions.
About this Structure
1WZ3 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
The crystal structure of plant ATG12 and its biological implication in autophagy., Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F, Autophagy. 2005 Jul;1(2):119-26. Epub 2005 Jul 23. PMID:16874047
Page seeded by OCA on Thu Mar 20 15:03:18 2008
