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4h4e

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h4e RCSB], [http://www.ebi.ac.uk/pdbsum/4h4e PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 14:21, 24 December 2014

IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate

4h4e, resolution 1.70Å

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