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2v6g
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V6G FirstGlance]. <br> | <table><tr><td colspan='2'>[[2v6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V6G FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v6f|2v6f]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v6f|2v6f]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v6g RCSB], [http://www.ebi.ac.uk/pdbsum/2v6g PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v6g RCSB], [http://www.ebi.ac.uk/pdbsum/2v6g PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q6PQJ9_DIGLA Q6PQJ9_DIGLA]] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Digitalis lanata]] | [[Category: Digitalis lanata]] | ||
| - | [[Category: Egerer-Sieber, C | + | [[Category: Egerer-Sieber, C]] |
| - | [[Category: Herl, V | + | [[Category: Herl, V]] |
| - | [[Category: Jaeger, C | + | [[Category: Jaeger, C]] |
| - | [[Category: Kreis, W | + | [[Category: Kreis, W]] |
| - | [[Category: Mueller-Uri, F | + | [[Category: Mueller-Uri, F]] |
| - | [[Category: Muller, Y A | + | [[Category: Muller, Y A]] |
| - | [[Category: Thorn, A | + | [[Category: Thorn, A]] |
[[Category: Cardenolide]] | [[Category: Cardenolide]] | ||
[[Category: Cardiac glycoside]] | [[Category: Cardiac glycoside]] | ||
Revision as of 15:52, 24 December 2014
STRUCTURE OF PROGESTERONE 5BETA-REDUCTASE FROM DIGITALIS LANATA IN COMPLEX WITH NADP
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