1xuq
From Proteopedia
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| - | [[Image:1xuq.gif|left|200px]] | + | [[Image:1xuq.gif|left|200px]] |
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| - | '''Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.''' | + | {{Structure |
| + | |PDB= 1xuq |SIZE=350|CAPTION= <scene name='initialview01'>1xuq</scene>, resolution 1.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] | ||
| + | |GENE= sodA1, sodA-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XUQ is a [ | + | 1XUQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUQ OCA]. |
==Reference== | ==Reference== | ||
| - | Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre., Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:[http:// | + | Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre., Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511113 16511113] |
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: soda-1; superoxide dismutase; bacillus anthracis; ba4499; spine]] | [[Category: soda-1; superoxide dismutase; bacillus anthracis; ba4499; spine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:14:46 2008'' |
Revision as of 13:14, 20 March 2008
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| , resolution 1.80Å | |||||||
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| Ligands: | |||||||
| Gene: | sodA1, sodA-1 (Bacillus anthracis) | ||||||
| Activity: | Superoxide dismutase, with EC number 1.15.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.
Overview
The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B. anthracis solved to high resolution are reported. Comparison of their structures reveals that a highly conserved residue near the active centre is substituted in one of the proteins and that this is a characteristic feature of superoxide dismutases from the B. cereus/B. anthracis/B. thuringiensis group of organisms.
About this Structure
1XUQ is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.
Reference
Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre., Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113
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