4kgg
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of light mutant2 and dcr3 complex== | |
| - | + | <StructureSection load='4kgg' size='340' side='right' caption='[[4kgg]], [[Resolution|resolution]] 2.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4kgg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGG FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4en0|4en0]], [[3k51|3k51]], [[3mi8|3mi8]], [[3mhd|3mhd]], [[4j6g|4j6g]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF6B, DCR3, TR6, UNQ186/PRO212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1488 Clostridium acetobutylicum]), TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kgg RCSB], [http://www.ebi.ac.uk/pdbsum/4kgg PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. | [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Clostridium acetobutylicum]] | [[Category: Clostridium acetobutylicum]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Bonanno, J B | + | [[Category: Bonanno, J B]] |
| - | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network | + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] |
| - | [[Category: Kumar, P R | + | [[Category: Kumar, P R]] |
| - | [[Category: Liu, W | + | [[Category: Liu, W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Nathenson, S G | + | [[Category: Nathenson, S G]] |
| - | [[Category: Toro, R | + | [[Category: Toro, R]] |
| - | [[Category: Zhan, C | + | [[Category: Zhan, C]] |
[[Category: Atoms-to-animals: the immune function network]] | [[Category: Atoms-to-animals: the immune function network]] | ||
[[Category: Bind tnf receptor hvem and ltbr]] | [[Category: Bind tnf receptor hvem and ltbr]] | ||
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[[Category: N-glycosylation]] | [[Category: N-glycosylation]] | ||
[[Category: New hvem]] | [[Category: New hvem]] | ||
| - | [[Category: New york structural genomics research consortium]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
| - | [[Category: Protein structure initiative]] | + | [[Category: PSI, Protein structure initiative]] |
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
[[Category: Secreted protein]] | [[Category: Secreted protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Tnf]] | [[Category: Tnf]] | ||
[[Category: Tnf14]] | [[Category: Tnf14]] | ||
[[Category: Tnfr]] | [[Category: Tnfr]] | ||
Revision as of 17:14, 24 December 2014
Crystal structure of light mutant2 and dcr3 complex
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Categories: Clostridium acetobutylicum | Homo sapiens | Almo, S C | Bonanno, J B | IFN, Atoms-to-Animals:.The Immune Function Network | Kumar, P R | Liu, W | Structural genomic | Nathenson, S G | Toro, R | Zhan, C | Atoms-to-animals: the immune function network | Bind tnf receptor hvem and ltbr | Cytokine | Cytokine-signaling protein complex | Dcr3 | Ifn | Immune system | Jelly-roll fold | Light | Ltbr | Membrane | N-glycosylation | New hvem | Nysgrc | PSI, Protein structure initiative | Psi-biology | Secreted protein | Tnf | Tnf14 | Tnfr
