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1zvb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zvb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZVB FirstGlance]. <br> | <table><tr><td colspan='2'>[[1zvb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZVB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zv7|1zv7]], [[1zv8|1zv8]], [[1zva|1zva]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zv7|1zv7]], [[1zv8|1zv8]], [[1zva|1zva]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zvb RCSB], [http://www.ebi.ac.uk/pdbsum/1zvb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zvb RCSB], [http://www.ebi.ac.uk/pdbsum/1zvb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Sars coronavirus]] | [[Category: Sars coronavirus]] | ||
| - | [[Category: Dai, J | + | [[Category: Dai, J]] |
| - | [[Category: Deng, Y | + | [[Category: Deng, Y]] |
| - | [[Category: Liu, J | + | [[Category: Liu, J]] |
| - | [[Category: Lu, M | + | [[Category: Lu, M]] |
| - | [[Category: Yong, W | + | [[Category: Yong, W]] |
| - | [[Category: Zheng, Q | + | [[Category: Zheng, Q]] |
[[Category: Coiled coil]] | [[Category: Coiled coil]] | ||
[[Category: Conformational change]] | [[Category: Conformational change]] | ||
[[Category: Membrane fusion]] | [[Category: Membrane fusion]] | ||
[[Category: S2]] | [[Category: S2]] | ||
| - | [[Category: Sars coronavirus]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
[[Category: Virus entry]] | [[Category: Virus entry]] | ||
Revision as of 17:39, 24 December 2014
A structure-based mechanism of SARS virus membrane fusion
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Categories: Sars coronavirus | Dai, J | Deng, Y | Liu, J | Lu, M | Yong, W | Zheng, Q | Coiled coil | Conformational change | Membrane fusion | S2 | Viral protein | Virus entry
