2jac
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jac RCSB], [http://www.ebi.ac.uk/pdbsum/2jac PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jac RCSB], [http://www.ebi.ac.uk/pdbsum/2jac PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLRX1_YEAST GLRX1_YEAST]] Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.<ref>PMID:9571241</ref> <ref>PMID:11875065</ref> <ref>PMID:12684511</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Atcc 18824]] | [[Category: Atcc 18824]] | ||
| - | [[Category: Hakansson, K O | + | [[Category: Hakansson, K O]] |
| - | [[Category: Winther, J R | + | [[Category: Winther, J R]] |
[[Category: Electron transport]] | [[Category: Electron transport]] | ||
[[Category: Glutaredoxin]] | [[Category: Glutaredoxin]] | ||
Revision as of 18:14, 24 December 2014
Glutaredoxin Grx1p C30S mutant from yeast
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