1ypz
From Proteopedia
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| - | [[Image:1ypz.gif|left|200px]] | + | [[Image:1ypz.gif|left|200px]] |
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| - | '''Immune receptor''' | + | {{Structure |
| + | |PDB= 1ypz |SIZE=350|CAPTION= <scene name='initialview01'>1ypz</scene>, resolution 3.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Immune receptor''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YPZ is a [ | + | 1YPZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPZ OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:[http:// | + | Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15821084 15821084] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: t-cell receptor gamma chain]] | [[Category: t-cell receptor gamma chain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:26:01 2008'' |
Revision as of 13:26, 20 March 2008
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| , resolution 3.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | B2M (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Immune receptor
Contents |
Overview
Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1YPZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:15821084
Page seeded by OCA on Thu Mar 20 15:26:01 2008
