1z4z

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[[Image:1z4z.gif|left|200px]]<br /><applet load="1z4z" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z4z.gif|left|200px]]
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caption="1z4z, resolution 2.500&Aring;" />
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'''Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))'''<br />
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{{Structure
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|PDB= 1z4z |SIZE=350|CAPTION= <scene name='initialview01'>1z4z</scene>, resolution 2.500&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID'>DAN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
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|GENE= HN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5])
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}}
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'''Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z4Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_5 Simian virus 5] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DAN:'>DAN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4Z OCA].
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1Z4Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_5 Simian virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4Z OCA].
==Reference==
==Reference==
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Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15893670 15893670]
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Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15893670 15893670]
[[Category: Exo-alpha-sialidase]]
[[Category: Exo-alpha-sialidase]]
[[Category: Simian virus 5]]
[[Category: Simian virus 5]]
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[[Category: tetramer]]
[[Category: tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:14 2008''

Revision as of 13:31, 20 March 2008

Image:1z4z.gif


PDB ID 1z4z

Drag the structure with the mouse to rotate
, resolution 2.500Å
Ligands: , and
Gene: HN (Simian virus 5)
Activity: Exo-alpha-sialidase, with EC number 3.2.1.18
Coordinates: save as pdb, mmCIF, xml



Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA(soaked with sialic acid, pH7.0))


Overview

The paramyxovirus hemagglutinin-neuraminidase (HN) functions in virus attachment to cells, cleavage of sialic acid from oligosaccharides, and stimulating membrane fusion during virus entry into cells. The structural basis for these diverse functions remains to be fully understood. We report the crystal structures of the parainfluenza virus 5 (SV5) HN and its complexes with sialic acid, the inhibitor DANA, and the receptor sialyllactose. SV5 HN shares common structural features with HN of Newcastle disease virus (NDV) and human parainfluenza 3 (HPIV3), but unlike the previously determined HN structures, the SV5 HN forms a tetramer in solution, which is thought to be the physiological oligomer. The sialyllactose complex reveals intact receptor within the active site, but no major conformational changes in the protein. The SV5 HN structures do not support previously proposed models for HN action in membrane fusion and suggest alternative mechanisms by which HN may promote virus entry into cells.

About this Structure

1Z4Z is a Single protein structure of sequence from Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:15893670

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