1vf7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vf7]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VF7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vf7]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VF7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1vf7 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1vf7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE]] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| - | [[Category: Akama, H | + | [[Category: Akama, H]] |
| - | [[Category: Kashiwagi, S | + | [[Category: Kashiwagi, S]] |
| - | [[Category: Matsuura, T | + | [[Category: Matsuura, T]] |
| - | [[Category: Nakae, T | + | [[Category: Nakae, T]] |
| - | [[Category: Nakagawa, A | + | [[Category: Nakagawa, A]] |
| - | [[Category: Tsukihara, T | + | [[Category: Tsukihara, T]] |
| - | [[Category: Yoneyama, H | + | [[Category: Yoneyama, H]] |
[[Category: Alpha hairpin]] | [[Category: Alpha hairpin]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 19:54, 24 December 2014
Crystal structure of the membrane fusion protein, MexA of the multidrug transporter
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