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2uv0
From Proteopedia
(Difference between revisions)
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<StructureSection load='2uv0' size='340' side='right' caption='[[2uv0]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2uv0' size='340' side='right' caption='[[2uv0]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2uv0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV0 OCA]. <br> | + | <table><tr><td colspan='2'>[[2uv0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UV0 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2uv0 PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.,Bottomley MJ, Muraglia E, Bazzo R, Carfi A J Biol Chem. 2007 May 4;282(18):13592-600. Epub 2007 Mar 15. PMID:17363368<ref>PMID:17363368</ref> | Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.,Bottomley MJ, Muraglia E, Bazzo R, Carfi A J Biol Chem. 2007 May 4;282(18):13592-600. Epub 2007 Mar 15. PMID:17363368<ref>PMID:17363368</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Transcriptional activator|Transcriptional activator]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 31: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| - | [[Category: Bazzo, R | + | [[Category: Bazzo, R]] |
| - | [[Category: Bottomley, M J | + | [[Category: Bottomley, M J]] |
| - | [[Category: Carfi, A | + | [[Category: Carfi, A]] |
| - | [[Category: Muraglia, E | + | [[Category: Muraglia, E]] |
[[Category: Acyl-homoserine lactone receptor]] | [[Category: Acyl-homoserine lactone receptor]] | ||
[[Category: Alpha-beta-alpha sandwich]] | [[Category: Alpha-beta-alpha sandwich]] | ||
Revision as of 19:59, 24 December 2014
STRUCTURE OF THE P. AERUGINOSA LASR LIGAND-BINDING DOMAIN BOUND TO ITS AUTOINDUCER
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