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2j8s

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j8s]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8S FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j8s]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iwg|1iwg]], [[1oy6|1oy6]], [[1oy8|1oy8]], [[1oy9|1oy9]], [[1oyd|1oyd]], [[1oye|1oye]], [[1t9t|1t9t]], [[1t9u|1t9u]], [[1t9v|1t9v]], [[1t9w|1t9w]], [[1t9x|1t9x]], [[1t9y|1t9y]], [[2gif|2gif]], [[2hrt|2hrt]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iwg|1iwg]], [[1oy6|1oy6]], [[1oy8|1oy8]], [[1oy9|1oy9]], [[1oyd|1oyd]], [[1oye|1oye]], [[1t9t|1t9t]], [[1t9u|1t9u]], [[1t9v|1t9v]], [[1t9w|1t9w]], [[1t9x|1t9x]], [[1t9y|1t9y]], [[2gif|2gif]], [[2hrt|2hrt]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8s RCSB], [http://www.ebi.ac.uk/pdbsum/2j8s PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8s RCSB], [http://www.ebi.ac.uk/pdbsum/2j8s PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Amstutz, P.]]
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[[Category: Amstutz, P]]
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[[Category: Briand, C.]]
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[[Category: Briand, C]]
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[[Category: Gruetter, M G.]]
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[[Category: Gruetter, M G]]
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[[Category: Sennhauser, G.]]
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[[Category: Sennhauser, G]]
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[[Category: Storchenegger, O.]]
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[[Category: Storchenegger, O]]
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance-inhibitor complex]]
[[Category: Antibiotic resistance-inhibitor complex]]

Revision as of 20:15, 24 December 2014

DRUG EXPORT PATHWAY OF MULTIDRUG EXPORTER ACRB REVEALED BY DARPIN INHIBITORS

2j8s, resolution 2.54Å

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