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1zoq
From Proteopedia
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| - | [[Image:1zoq.gif|left|200px]] | + | [[Image:1zoq.gif|left|200px]] |
| - | + | ||
| - | '''IRF3-CBP complex''' | + | {{Structure |
| + | |PDB= 1zoq |SIZE=350|CAPTION= <scene name='initialview01'>1zoq</scene>, resolution 2.37Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] | ||
| + | |GENE= IRF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CREBBP, CBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''IRF3-CBP complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZOQ is a [ | + | 1ZOQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA]. |
==Reference== | ==Reference== | ||
| - | IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:[http:// | + | IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16154077 16154077] |
[[Category: Histone acetyltransferase]] | [[Category: Histone acetyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:03 2008'' |
Revision as of 13:38, 20 March 2008
| |||||||
| , resolution 2.37Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | IRF3 (Homo sapiens), CREBBP, CBP (Homo sapiens) | ||||||
| Activity: | Histone acetyltransferase, with EC number 2.3.1.48 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
IRF3-CBP complex
Contents |
Overview
Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.
Disease
Known diseases associated with this structure: Blue-cone monochromacy OMIM:[303900], Colorblindness, protan OMIM:[303900], Rubenstein-Taybi syndrome OMIM:[600140]
About this Structure
1ZOQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:16154077
Page seeded by OCA on Thu Mar 20 15:38:03 2008
