2e2c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br> | <table><tr><td colspan='2'>[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2c RCSB], [http://www.ebi.ac.uk/pdbsum/2e2c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Spisula solidissima]] | [[Category: Spisula solidissima]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
| - | [[Category: Basavappa, R | + | [[Category: Basavappa, R]] |
| - | [[Category: Jiang, F | + | [[Category: Jiang, F]] |
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Thioester bond]] | [[Category: Thioester bond]] | ||
[[Category: Ubiquitin carrier protein]] | [[Category: Ubiquitin carrier protein]] | ||
[[Category: Ubiquitin conjugation]] | [[Category: Ubiquitin conjugation]] | ||
Revision as of 21:01, 24 December 2014
E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS
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