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2vas
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VAS FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VAS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bkh|2bkh]], [[2v26|2v26]], [[2bki|2bki]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bkh|2bkh]], [[2v26|2v26]], [[2bki|2bki]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vas RCSB], [http://www.ebi.ac.uk/pdbsum/2vas PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vas RCSB], [http://www.ebi.ac.uk/pdbsum/2vas PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[http://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Calmodulin|Calmodulin]] | ||
*[[Myosin|Myosin]] | *[[Myosin|Myosin]] | ||
== References == | == References == | ||
| Line 35: | Line 36: | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Cicolari, J | + | [[Category: Cicolari, J]] |
| - | [[Category: Houdusse, A | + | [[Category: Houdusse, A]] |
| - | [[Category: Li, A | + | [[Category: Li, A]] |
| - | [[Category: Liu, X | + | [[Category: Liu, X]] |
| - | [[Category: Llinas, P | + | [[Category: Llinas, P]] |
| - | [[Category: Menetrey, J | + | [[Category: Menetrey, J]] |
| - | [[Category: Squires, G | + | [[Category: Squires, G]] |
| - | [[Category: Sweeney, H L | + | [[Category: Sweeney, H L]] |
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
Revision as of 21:52, 24 December 2014
MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) POST-RIGOR STATE
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Categories: Drosophila melanogaster | Sus scrofa | Cicolari, J | Houdusse, A | Li, A | Liu, X | Llinas, P | Menetrey, J | Squires, G | Sweeney, H L | Actin-binding | Atp-binding | Calmodulin | Calmodulin-binding | Cam | Endocytosis | Golgi apparatus | Membrane | Mg adp befx | Molecular motor | Motor protein | Myosin | Myosin vi | Nucleotide-binding | Nucleus | Phosphorylation | Post-rigor state | Protein transport | Transport
