This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1l5i
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L5I FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L5I FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l2m|1l2m]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l2m|1l2m]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=123735 Tomato yellow leaf curl Sardinia virus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=123735 Tomato yellow leaf curl Sardinia virus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l5i RCSB], [http://www.ebi.ac.uk/pdbsum/1l5i PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l5i RCSB], [http://www.ebi.ac.uk/pdbsum/1l5i PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/REP_TYCSV REP_TYCSV]] Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Tomato yellow leaf curl sardinia virus]] | [[Category: Tomato yellow leaf curl sardinia virus]] | ||
| - | [[Category: Campos-Olivas, R | + | [[Category: Campos-Olivas, R]] |
| - | [[Category: Clerot, D | + | [[Category: Clerot, D]] |
| - | [[Category: Gronenborn, A M | + | [[Category: Gronenborn, A M]] |
| - | [[Category: Gronenborn, B | + | [[Category: Gronenborn, B]] |
| - | [[Category: Louis, J M | + | [[Category: Louis, J M]] |
[[Category: A+b fold]] | [[Category: A+b fold]] | ||
[[Category: Rbd-like fold]] | [[Category: Rbd-like fold]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 21:53, 24 December 2014
30-CONFORMER NMR ENSEMBLE OF THE N-TERMINAL, DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN FROM A GEMINIVIRUS (TOMATO YELLOW LEAF CURL VIRUS-SARDINIA)
| |||||||||||
