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2gpq
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gpq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gpq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPQ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpq RCSB], [http://www.ebi.ac.uk/pdbsum/2gpq PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpq RCSB], [http://www.ebi.ac.uk/pdbsum/2gpq PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Borden, K L.B | + | [[Category: Borden, K L.B]] |
| - | [[Category: Osborne, M J | + | [[Category: Osborne, M J]] |
| - | [[Category: Volpon, L | + | [[Category: Volpon, L]] |
[[Category: Apo form]] | [[Category: Apo form]] | ||
[[Category: Eif4e]] | [[Category: Eif4e]] | ||
[[Category: Translation]] | [[Category: Translation]] | ||
[[Category: Translation regulation]] | [[Category: Translation regulation]] | ||
Revision as of 22:05, 24 December 2014
Cap-free structure of eIF4E suggests basis for its allosteric regulation
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