This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3azl
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azl RCSB], [http://www.ebi.ac.uk/pdbsum/3azl PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azl RCSB], [http://www.ebi.ac.uk/pdbsum/3azl PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 25: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Iwasaki, W | + | [[Category: Iwasaki, W]] |
| - | [[Category: Kagawa, W | + | [[Category: Kagawa, W]] |
| - | [[Category: Kawaguchi, K | + | [[Category: Kawaguchi, K]] |
| - | [[Category: Kurumizaka, H | + | [[Category: Kurumizaka, H]] |
| - | [[Category: Shibata, T | + | [[Category: Shibata, T]] |
| - | [[Category: Tachiwana, H | + | [[Category: Tachiwana, H]] |
[[Category: Histone-fold]] | [[Category: Histone-fold]] | ||
[[Category: Nucleosome]] | [[Category: Nucleosome]] | ||
[[Category: Structural protein-dna complex]] | [[Category: Structural protein-dna complex]] | ||
Revision as of 23:26, 24 December 2014
Crystal Structure of Human Nucleosome Core Particle Containing H4K77Q mutation
| |||||||||||
