4l8z
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l8z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l8z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RL1:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](3,4-DIHYDROISOQUINOLIN-2(1H)-YL)METHANONE'>RL1</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RL1:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](3,4-DIHYDROISOQUINOLIN-2(1H)-YL)METHANONE'>RL1</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l90|4l90]], [[4l91|4l91]], [[4l93|4l93]], [[4l94|4l94]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l90|4l90]], [[4l91|4l91]], [[4l93|4l93]], [[4l94|4l94]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8z RCSB], [http://www.ebi.ac.uk/pdbsum/4l8z PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8z RCSB], [http://www.ebi.ac.uk/pdbsum/4l8z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: He, J | + | [[Category: He, J]] |
| - | [[Category: Li, J | + | [[Category: Li, J]] |
| - | [[Category: Ren, J | + | [[Category: Ren, J]] |
| - | [[Category: Xiong, B | + | [[Category: Xiong, B]] |
| - | [[Category: Yang, M | + | [[Category: Yang, M]] |
[[Category: Atp hydrolysis]] | [[Category: Atp hydrolysis]] | ||
[[Category: Chaperone-chaperone inhibitor complex]] | [[Category: Chaperone-chaperone inhibitor complex]] | ||
[[Category: Hsp90n-hsp90n inhibitor complex]] | [[Category: Hsp90n-hsp90n inhibitor complex]] | ||
Revision as of 00:04, 25 December 2014
Crystal structure of Human Hsp90 with RL1
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