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4bkw
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the C-terminal region of human ZFYVE9== | |
| - | + | <StructureSection load='4bkw' size='340' side='right' caption='[[4bkw]], [[Resolution|resolution]] 2.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4bkw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKW FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkw RCSB], [http://www.ebi.ac.uk/pdbsum/4bkw PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/ZFYV9_HUMAN ZFYV9_HUMAN]] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.<ref>PMID:9865696</ref> <ref>PMID:15356634</ref> | [[http://www.uniprot.org/uniprot/ZFYV9_HUMAN ZFYV9_HUMAN]] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.<ref>PMID:9865696</ref> <ref>PMID:15356634</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | <references | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Bullock, A | + | [[Category: Bullock, A]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Shrestha, L | + | [[Category: Shrestha, L]] |
| - | [[Category: Vollmar, M | + | [[Category: Vollmar, M]] |
| - | [[Category: Williams, E | + | [[Category: Williams, E]] |
[[Category: Protein interaction domain]] | [[Category: Protein interaction domain]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Tgf-beta and egfr signalling]] | [[Category: Tgf-beta and egfr signalling]] | ||
Revision as of 01:01, 25 December 2014
Crystal structure of the C-terminal region of human ZFYVE9
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