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3bkz
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bkz RCSB], [http://www.ebi.ac.uk/pdbsum/3bkz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bkz RCSB], [http://www.ebi.ac.uk/pdbsum/3bkz PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Ecoli]] | [[Category: Ecoli]] | ||
| - | [[Category: He, C | + | [[Category: He, C]] |
| - | [[Category: Yang, C G | + | [[Category: Yang, C G]] |
| - | [[Category: Yi, C | + | [[Category: Yi, C]] |
[[Category: Alkylation repair]] | [[Category: Alkylation repair]] | ||
[[Category: Cross-linking]] | [[Category: Cross-linking]] | ||
Revision as of 01:10, 25 December 2014
X-ray structure of E coli AlkB crosslinked to dsDNA in the active site
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