2as0

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[[Image:2as0.gif|left|200px]]<br /><applet load="2as0" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2as0.gif|left|200px]]
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caption="2as0, resolution 1.80&Aring;" />
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'''Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase'''<br />
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{{Structure
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|PDB= 2as0 |SIZE=350|CAPTION= <scene name='initialview01'>2as0</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= PH1915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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}}
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'''Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2AS0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AS0 OCA].
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2AS0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AS0 OCA].
==Reference==
==Reference==
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The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16260766 16260766]
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The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16260766 16260766]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Xu, X.]]
[[Category: Xu, X.]]
[[Category: mcsg]]
[[Category: mcsg]]
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[[Category: midwest center for structural genomics]]
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[[Category: midwest center for structural genomic]]
[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
[[Category: rna methyltransferase]]
[[Category: rna methyltransferase]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:30:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:53:11 2008''

Revision as of 13:53, 20 March 2008

Image:2as0.gif


PDB ID 2as0

Drag the structure with the mouse to rotate
, resolution 1.80Å
Gene: PH1915 (Pyrococcus horikoshii)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase


Overview

The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.

About this Structure

2AS0 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:16260766

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