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3nr9
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3nr9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLK2_HUMAN CLK2_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> <ref>PMID:8910305</ref> <ref>PMID:9637771</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Dual specificity protein kinase|Dual specificity protein kinase]] | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 01:35, 25 December 2014
Structure of human CDC2-like kinase 2 (CLK2)
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Categories: Dual-specificity kinase | Homo sapiens | Arrowsmith, C H | Berridge, G | Bountra, C | Chaikuad, A | Delft, F von | Edwards, A M | Eswaran, J | Fedorov, O | Filippakopoulos, P | Keates, T | Knapp, S | Krojer, T | Muniz, J R.C | Phillips, C | Pike, A C.W | Rellos, P | Structural genomic | Savitsky, P | Weigelt, J | Zhang, Y | Dual specificity protein kinase | Protein kinase | Sgc | Transferase
