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4u4g
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4g RCSB], [http://www.ebi.ac.uk/pdbsum/4u4g PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4g RCSB], [http://www.ebi.ac.uk/pdbsum/4u4g PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Li, M | + | [[Category: Li, M]] |
| - | [[Category: Sobolevsky, A I | + | [[Category: Sobolevsky, A I]] |
| - | [[Category: Yelshanskaya, M V | + | [[Category: Yelshanskaya, M V]] |
[[Category: Ampa receptor]] | [[Category: Ampa receptor]] | ||
[[Category: Competitive antagonist]] | [[Category: Competitive antagonist]] | ||
Revision as of 01:41, 25 December 2014
Structure of GluA2* in complex with competitive antagonist ZK 200775
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