2b0s
From Proteopedia
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| - | [[Image:2b0s.gif|left|200px]] | + | [[Image:2b0s.gif|left|200px]] |
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| - | '''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide''' | + | {{Structure |
| + | |PDB= 2b0s |SIZE=350|CAPTION= <scene name='initialview01'>2b0s</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B0S is a [ | + | 2B0S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0S OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:[http:// | + | Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16731948 16731948] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: fab-peptide complex; hiv-1; gp120; v3 loop]] | [[Category: fab-peptide complex; hiv-1; gp120; v3 loop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:09 2008'' |
Revision as of 13:56, 20 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide
Overview
Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
About this Structure
2B0S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:16731948
Page seeded by OCA on Thu Mar 20 15:56:09 2008
