This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2b5i
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2b5i.gif|left|200px]] | + | [[Image:2b5i.gif|left|200px]] |
| - | + | ||
| - | '''cytokine receptor complex''' | + | {{Structure |
| + | |PDB= 2b5i |SIZE=350|CAPTION= <scene name='initialview01'>2b5i</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= IL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL2RB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL2RG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL2RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''cytokine receptor complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2B5I is a [ | + | 2B5I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5I OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors., Wang X, Rickert M, Garcia KC, Science. 2005 Nov 18;310(5751):1159-63. PMID:[http:// | + | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors., Wang X, Rickert M, Garcia KC, Science. 2005 Nov 18;310(5751):1159-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16293754 16293754] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 23: | Line 32: | ||
[[Category: four-helix bundle]] | [[Category: four-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:57:49 2008'' |
Revision as of 13:57, 20 March 2008
| |||||||
| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | IL2 (Homo sapiens), IL2RB (Homo sapiens), IL2RG (Homo sapiens), IL2RA (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
cytokine receptor complex
Contents |
Overview
Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.
Disease
Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[308380], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680], Severe combined immunodeficiency, X-linked OMIM:[308380]
About this Structure
2B5I is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors., Wang X, Rickert M, Garcia KC, Science. 2005 Nov 18;310(5751):1159-63. PMID:16293754
Page seeded by OCA on Thu Mar 20 15:57:49 2008
