3n4m
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n4m RCSB], [http://www.ebi.ac.uk/pdbsum/3n4m PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n4m RCSB], [http://www.ebi.ac.uk/pdbsum/3n4m PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> [[http://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059] | ||
==See Also== | ==See Also== | ||
*[[Catabolite gene activator protein|Catabolite gene activator protein]] | *[[Catabolite gene activator protein|Catabolite gene activator protein]] | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase|RNA polymerase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 03:35, 25 December 2014
E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA
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