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2vij
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VIJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VIJ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C44:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(1S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLAMINO]PROPYL}-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>C44</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C44:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(1S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLAMINO]PROPYL}-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>C44</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m4h|1m4h]], [[1sgz|1sgz]], [[1w50|1w50]], [[1w51|1w51]], [[1xs7|1xs7]], [[1ym4|1ym4]], [[1fkn|1fkn]], [[1py1|1py1]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1ym2|1ym2]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2va5|2va5]], [[2va6|2va6]], [[2va7|2va7]], [[2vie|2vie]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m4h|1m4h]], [[1sgz|1sgz]], [[1w50|1w50]], [[1w51|1w51]], [[1xs7|1xs7]], [[1ym4|1ym4]], [[1fkn|1fkn]], [[1py1|1py1]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1ym2|1ym2]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2va5|2va5]], [[2va6|2va6]], [[2va7|2va7]], [[2vie|2vie]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vij RCSB], [http://www.ebi.ac.uk/pdbsum/2vij PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vij RCSB], [http://www.ebi.ac.uk/pdbsum/2vij PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
| - | [[Category: Beswick, P | + | [[Category: Beswick, P]] |
| - | [[Category: Brien, A O | + | [[Category: Brien, A O]] |
| - | [[Category: Charrier, N | + | [[Category: Charrier, N]] |
| - | [[Category: Clarke, B | + | [[Category: Clarke, B]] |
| - | [[Category: Demont, E | + | [[Category: Demont, E]] |
| - | [[Category: Dingwall, C | + | [[Category: Dingwall, C]] |
| - | [[Category: Dunsdon, R | + | [[Category: Dunsdon, R]] |
| - | [[Category: Faller, A | + | [[Category: Faller, A]] |
| - | [[Category: Gleave, R | + | [[Category: Gleave, R]] |
| - | [[Category: Hawkins, J | + | [[Category: Hawkins, J]] |
| - | [[Category: Hussain, I | + | [[Category: Hussain, I]] |
| - | [[Category: Johnson, C N | + | [[Category: Johnson, C N]] |
| - | [[Category: Macpherson, D | + | [[Category: Macpherson, D]] |
| - | [[Category: Maile, G | + | [[Category: Maile, G]] |
| - | [[Category: Matico, R | + | [[Category: Matico, R]] |
| - | [[Category: Milner, P | + | [[Category: Milner, P]] |
| - | [[Category: Mosley, J | + | [[Category: Mosley, J]] |
| - | [[Category: Naylor, A | + | [[Category: Naylor, A]] |
| - | [[Category: Redshaw, S | + | [[Category: Redshaw, S]] |
| - | [[Category: Riddell, D | + | [[Category: Riddell, D]] |
| - | [[Category: Rowland, P | + | [[Category: Rowland, P]] |
| - | [[Category: Skidmore, J | + | [[Category: Skidmore, J]] |
| - | [[Category: Smith, K J | + | [[Category: Smith, K J]] |
| - | [[Category: Soleil, V | + | [[Category: Soleil, V]] |
| - | [[Category: Stanway, S | + | [[Category: Stanway, S]] |
| - | [[Category: Stemp, G | + | [[Category: Stemp, G]] |
| - | [[Category: Stuart, A | + | [[Category: Stuart, A]] |
| - | [[Category: Sweitzer, S | + | [[Category: Sweitzer, S]] |
| - | [[Category: Theobald, P | + | [[Category: Theobald, P]] |
| - | [[Category: Vesey, D | + | [[Category: Vesey, D]] |
| - | [[Category: Walter, D S | + | [[Category: Walter, D S]] |
| - | [[Category: Ward, J | + | [[Category: Ward, J]] |
| - | [[Category: Wayne, G | + | [[Category: Wayne, G]] |
[[Category: Asp-2]] | [[Category: Asp-2]] | ||
[[Category: Aspartyl protease]] | [[Category: Aspartyl protease]] | ||
Revision as of 03:58, 25 December 2014
HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(1,2,3,4-TETRAHYDRO-1-NAPHTHALENYLAMINO) PROPYL)BENZAMIDE
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Categories: Homo sapiens | Memapsin 2 | Beswick, P | Brien, A O | Charrier, N | Clarke, B | Demont, E | Dingwall, C | Dunsdon, R | Faller, A | Gleave, R | Hawkins, J | Hussain, I | Johnson, C N | Macpherson, D | Maile, G | Matico, R | Milner, P | Mosley, J | Naylor, A | Redshaw, S | Riddell, D | Rowland, P | Skidmore, J | Smith, K J | Soleil, V | Stanway, S | Stemp, G | Stuart, A | Sweitzer, S | Theobald, P | Vesey, D | Walter, D S | Ward, J | Wayne, G | Asp-2 | Aspartyl protease | Bace-1 | Beta-secretase | Beta-site app cleaving enzyme | Glycoprotein | Hydrolase | Memapsin-2 | Membrane | Protease | Transmembrane | Zymogen
