This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1tey
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tey]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TEY FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tey]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TEY FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASF1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASF1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tey RCSB], [http://www.ebi.ac.uk/pdbsum/1tey PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tey RCSB], [http://www.ebi.ac.uk/pdbsum/1tey PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Agez, M | + | [[Category: Agez, M]] |
| - | [[Category: Amigues, B | + | [[Category: Amigues, B]] |
| - | [[Category: Courbeyrette, R | + | [[Category: Courbeyrette, R]] |
| - | [[Category: Guerois, R | + | [[Category: Guerois, R]] |
| - | [[Category: Lautrette, A | + | [[Category: Lautrette, A]] |
| - | [[Category: Mann, C | + | [[Category: Mann, C]] |
| - | [[Category: Mousson, F | + | [[Category: Mousson, F]] |
| - | [[Category: Neumann, J M | + | [[Category: Neumann, J M]] |
| - | [[Category: Ochsenbein, F | + | [[Category: Ochsenbein, F]] |
| - | [[Category: Thuret, J Y | + | [[Category: Thuret, J Y]] |
[[Category: Beta-sandwich]] | [[Category: Beta-sandwich]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Distorted immunoglobulin-like]] | [[Category: Distorted immunoglobulin-like]] | ||
Revision as of 04:08, 25 December 2014
NMR structure of human histone chaperone, ASF1A
| |||||||||||
