1l2h
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2H FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2H FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[9ilb|9ilb]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[9ilb|9ilb]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2h RCSB], [http://www.ebi.ac.uk/pdbsum/1l2h PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2h RCSB], [http://www.ebi.ac.uk/pdbsum/1l2h PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Heidary, D K | + | [[Category: Heidary, D K]] |
| - | [[Category: Jennings, P A | + | [[Category: Jennings, P A]] |
| - | [[Category: Kelker, M S | + | [[Category: Kelker, M S]] |
| - | [[Category: Oseroff, V | + | [[Category: Oseroff, V]] |
| - | [[Category: Rudolph, M G | + | [[Category: Rudolph, M G]] |
| - | [[Category: Schneider, T R | + | [[Category: Schneider, T R]] |
| - | [[Category: Wilson, I A | + | [[Category: Wilson, I A]] |
| - | [[Category: Yeates, T O | + | [[Category: Yeates, T O]] |
[[Category: Beta-trefoil]] | [[Category: Beta-trefoil]] | ||
[[Category: F42w/w120f double mutant]] | [[Category: F42w/w120f double mutant]] | ||
Revision as of 04:15, 25 December 2014
Crystal structure of Interleukin 1-beta F42W/W120F mutant
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