This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1y7k
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y7k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7K FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y7k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7K FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y7j|1y7j]], [[1hyk|1hyk]], [[1mr0|1mr0]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y7j|1y7j]], [[1hyk|1hyk]], [[1mr0|1mr0]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7k RCSB], [http://www.ebi.ac.uk/pdbsum/1y7k PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7k RCSB], [http://www.ebi.ac.uk/pdbsum/1y7k PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 28: | Line 30: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Barsh, G S | + | [[Category: Barsh, G S]] |
| - | [[Category: Chai, B | + | [[Category: Chai, B]] |
| - | [[Category: Dawson, P E | + | [[Category: Dawson, P E]] |
| - | [[Category: Gantz, I | + | [[Category: Gantz, I]] |
| - | [[Category: Jackson, P J | + | [[Category: Jackson, P J]] |
| - | [[Category: McNulty, J C | + | [[Category: McNulty, J C]] |
| - | [[Category: Millhauser, G L | + | [[Category: Millhauser, G L]] |
| - | [[Category: Thompson, D A | + | [[Category: Thompson, D A]] |
[[Category: Cystine knot]] | [[Category: Cystine knot]] | ||
[[Category: Endogenous antagonist]] | [[Category: Endogenous antagonist]] | ||
Revision as of 04:34, 25 December 2014
NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)
| |||||||||||
