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3pmo

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[[Image:3pmo.png|left|200px]]
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==The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution==
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<StructureSection load='3pmo' size='340' side='right' caption='[[3pmo]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PMO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxD, PA3646 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pmo RCSB], [http://www.ebi.ac.uk/pdbsum/3pmo PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LPXD_PSEAE LPXD_PSEAE]] Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.[HAMAP-Rule:MF_00523]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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LpxD is a bacterial protein that is part of the biosynthesis pathway of lipid A and is responsible for transferring 3-hydroxymyristic acid from the R-3-hydroxymyristoyl-acyl carrier protein to the 2-OH group of UDP-3-O-(3-hydroxymyristoyl) glucosamine. The crystal structure of LpxD from Pseudomonas aeruginosa has been determined at high resolution (1.3 A). The crystal belonged to space group H3, with unit-cell parameters a=b=106.19, c=93.38 A, and contained one molecule in the asymmetric unit. The structure was solved by molecular replacement using the known structure of LpxD from Escherichia coli (PDB entry 3eh0) as a search model and was refined to Rwork=16.4% (Rfree=18.5%) using 91,655 reflections. The final protein model includes 355 amino-acid residues (including 16 amino acids from a 20 amino-acid N-terminal His tag), one chloride ion and two ethylene glycol molecules.
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<!--
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The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution.,Badger J, Chie-Leon B, Logan C, Sridhar V, Sankaran B, Zwart PH, Nienaber V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):749-52., Epub 2011 Jun 23. PMID:21795786<ref>PMID:21795786</ref>
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The line below this paragraph, containing "STRUCTURE_3pmo", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_3pmo| PDB=3pmo | SCENE= }}
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===The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21795786}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21795786 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_21795786}}
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==About this Structure==
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[[3pmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMO OCA].
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==Reference==
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<ref group="xtra">PMID:021795786</ref><references group="xtra"/>
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Badger, J.]]
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[[Category: Badger, J]]
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[[Category: Chie-Leon, B.]]
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[[Category: Chie-Leon, B]]
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[[Category: Logan, C.]]
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[[Category: Logan, C]]
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[[Category: Nienaber, V.]]
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[[Category: Nienaber, V]]
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[[Category: Sankaran, B.]]
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[[Category: Sankaran, B]]
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[[Category: Sridhar, V.]]
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[[Category: Sridhar, V]]
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[[Category: Zwart, P H.]]
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[[Category: Zwart, P H]]
[[Category: Lipid a biosynthesis pathway]]
[[Category: Lipid a biosynthesis pathway]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 04:55, 25 December 2014

The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution

3pmo, resolution 1.30Å

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