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1u7z
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u7z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U7Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[1u7z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U7Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMT:PHOSPHORIC+ACID+MONO-[3-(3-{[5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-3,4-+DIHYDROXY-TETRAHYDRO-FURAN-2-+YLMETHOXY]-HYDROXY-PHOSPHORYLOXY}-3-OXO-PROPYLCARBAMOYL)-3-HYDROXY-2,2-+DIMETHYL-PROPYL]+ESTER'>PMT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMT:PHOSPHORIC+ACID+MONO-[3-(3-{[5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-3,4-+DIHYDROXY-TETRAHYDRO-FURAN-2-+YLMETHOXY]-HYDROXY-PHOSPHORYLOXY}-3-OXO-PROPYLCARBAMOYL)-3-HYDROXY-2,2-+DIMETHYL-PROPYL]+ESTER'>PMT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u7u|1u7u]], [[1u7w|1u7w]], [[1u80|1u80]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u7u|1u7u]], [[1u7w|1u7w]], [[1u80|1u80]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphopantothenate--cysteine_ligase Phosphopantothenate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.5 6.3.2.5] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphopantothenate--cysteine_ligase Phosphopantothenate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.5 6.3.2.5] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u7z RCSB], [http://www.ebi.ac.uk/pdbsum/1u7z PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u7z RCSB], [http://www.ebi.ac.uk/pdbsum/1u7z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COABC_ECOLI COABC_ECOLI]] Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Phosphopantothenate--cysteine ligase]] | [[Category: Phosphopantothenate--cysteine ligase]] | ||
| - | [[Category: Augustin, M A | + | [[Category: Augustin, M A]] |
| - | [[Category: Huber, R | + | [[Category: Huber, R]] |
| - | [[Category: Kupke, T | + | [[Category: Kupke, T]] |
| - | [[Category: Stanitzek, S | + | [[Category: Stanitzek, S]] |
| - | [[Category: Steinbacher, S | + | [[Category: Steinbacher, S]] |
[[Category: Coenzyme a biosynthesis]] | [[Category: Coenzyme a biosynthesis]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 05:03, 25 December 2014
Phosphopantothenoylcysteine synthetase from E. coli, 4'-phosphopantothenoyl-CMP complex
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