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3psl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PSL FirstGlance]. <br> | <table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PSL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [http://www.ebi.ac.uk/pdbsum/3psl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [http://www.ebi.ac.uk/pdbsum/3psl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.,Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF FASEB J. 2010 Dec 6. PMID:21135039<ref>PMID:21135039</ref> | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.,Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF FASEB J. 2010 Dec 6. PMID:21135039<ref>PMID:21135039</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Avdic, V | + | [[Category: Avdic, V]] |
| - | [[Category: Couture, J F | + | [[Category: Couture, J F]] |
| - | [[Category: Lanouette, S | + | [[Category: Lanouette, S]] |
| - | [[Category: Skerjanc, I | + | [[Category: Skerjanc, I]] |
| - | [[Category: Voronova, A | + | [[Category: Voronova, A]] |
| - | [[Category: Zhang, P | + | [[Category: Zhang, P]] |
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Chromatin]] | [[Category: Chromatin]] | ||
Revision as of 05:59, 25 December 2014
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic
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