This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2mij
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==NMR structure of the S-linked glycopeptide sublancin 168== | |
| - | + | <StructureSection load='2mij' size='340' side='right' caption='[[2mij]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIJ FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mij RCSB], [http://www.ebi.ac.uk/pdbsum/2mij PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/SUNA_BACSU SUNA_BACSU]] Bacteriocin active against Gram-positive bacteria. Inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than it inhibits exponential growth of the same cells. Inhibits B.subtilis strain ATCC 6633.<ref>PMID:21196935</ref> | [[http://www.uniprot.org/uniprot/SUNA_BACSU SUNA_BACSU]] Bacteriocin active against Gram-positive bacteria. Inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than it inhibits exponential growth of the same cells. Inhibits B.subtilis strain ATCC 6633.<ref>PMID:21196935</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sublancin 168 is a member of a small group of glycosylated antimicrobial peptides known as glycocins. The solution structure of sublancin 168, a 37-amino-acid peptide produced by Bacillus subtilis 168, has been solved by nuclear magnetic resonance (NMR) spectroscopy. Sublancin comprises two alpha-helices and a well-defined interhelical loop. The two helices span residues 6-16 and 26-35, and the loop region encompasses residues 17-25. The 9-amino-acid loop region contains a beta-S-linked glucose moiety attached to Cys22. Hydrophobic interactions as well as hydrogen bonding are responsible for the well-structured loop region. The three-dimensional structure provides an explanation for the previously reported extraordinary high stability of sublancin 168. | ||
| - | + | NMR Structure of the S-Linked Glycopeptide Sublancin 168.,Garcia De Gonzalo CV, Zhu L, Oman TJ, van der Donk WA ACS Chem Biol. 2014 Jan 17. PMID:24405370<ref>PMID:24405370</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Donk, W A.van der | + | [[Category: Donk, W A.van der]] |
| - | [[Category: Gonzalo, C V.Garcia De | + | [[Category: Gonzalo, C V.Garcia De]] |
| - | [[Category: Oman, T J | + | [[Category: Oman, T J]] |
| - | [[Category: Zhu, L | + | [[Category: Zhu, L]] |
[[Category: Antimicrobial protein]] | [[Category: Antimicrobial protein]] | ||
[[Category: Glycopeptide]] | [[Category: Glycopeptide]] | ||
Revision as of 06:11, 25 December 2014
NMR structure of the S-linked glycopeptide sublancin 168
| |||||||||||
