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2jex

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jex]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]], [[2jeu|2jeu]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]], [[2jeu|2jeu]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [http://www.ebi.ac.uk/pdbsum/2jex PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB], [http://www.ebi.ac.uk/pdbsum/2jex PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Bovine papillomavirus type 1]]
[[Category: Bovine papillomavirus type 1]]
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[[Category: Antson, A A.]]
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[[Category: Antson, A A]]
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[[Category: Ortiz-Lombardia, M.]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Sanders, C M.]]
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[[Category: Sanders, C M]]
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[[Category: Seavers, P R.]]
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[[Category: Seavers, P R]]
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[[Category: Sizov, D.]]
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[[Category: Sizov, D]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Bovine papillomavirus]]
[[Category: Bovine papillomavirus]]

Revision as of 06:24, 25 December 2014

TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION

2jex, resolution 2.35Å

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