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4ri0
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ri0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ri0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ri0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ri0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ri0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ri0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ri0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ri0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HTRA3_HUMAN HTRA3_HUMAN]] Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.<ref>PMID:21321049</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Glaza, P | + | [[Category: Glaza, P]] |
| - | [[Category: Joachimiak, A | + | [[Category: Joachimiak, A]] |
| - | [[Category: Lipinska, B | + | [[Category: Lipinska, B]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Osipiuk, J | + | [[Category: Osipiuk, J]] |
| - | [[Category: Wenta, T | + | [[Category: Wenta, T]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
| - | [[Category: Midwest center for structural genomic]] | ||
[[Category: National science center - poland]] | [[Category: National science center - poland]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 08:39, 25 December 2014
Serine Protease HtrA3, mutationally inactivated
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