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1y7j
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y7j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7J FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y7k|1y7k]], [[1hyk|1hyk]], [[1mr0|1mr0]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y7k|1y7k]], [[1hyk|1hyk]], [[1mr0|1mr0]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7j RCSB], [http://www.ebi.ac.uk/pdbsum/1y7j PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASIP_HUMAN ASIP_HUMAN]] Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Barsh, G S | + | [[Category: Barsh, G S]] |
| - | [[Category: Chai, B | + | [[Category: Chai, B]] |
| - | [[Category: Dawson, P E | + | [[Category: Dawson, P E]] |
| - | [[Category: Gantz, I | + | [[Category: Gantz, I]] |
| - | [[Category: Jackson, P J | + | [[Category: Jackson, P J]] |
| - | [[Category: McNulty, J C | + | [[Category: McNulty, J C]] |
| - | [[Category: Millhauser, G L | + | [[Category: Millhauser, G L]] |
| - | [[Category: Thompson, D A | + | [[Category: Thompson, D A]] |
[[Category: Cystine knot]] | [[Category: Cystine knot]] | ||
[[Category: Endogenous antagonist]] | [[Category: Endogenous antagonist]] | ||
Revision as of 09:24, 25 December 2014
NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)
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