1mzc
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZC FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MZC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNE:2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE'>BNE</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNE:2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE'>BNE</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ld7|1ld7]], [[1ld8|1ld8]], [[1jcq|1jcq]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ld7|1ld7]], [[1ld8|1ld8]], [[1jcq|1jcq]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzc RCSB], [http://www.ebi.ac.uk/pdbsum/1mzc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mzc RCSB], [http://www.ebi.ac.uk/pdbsum/1mzc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FNTA_HUMAN FNTA_HUMAN]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_HUMAN FNTB_HUMAN]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Beese, L S | + | [[Category: Beese, L S]] |
| - | [[Category: Buser, C A | + | [[Category: Buser, C A]] |
| - | [[Category: Ciccarone, T M | + | [[Category: Ciccarone, T M]] |
| - | [[Category: Ellis-Hutchings, M | + | [[Category: Ellis-Hutchings, M]] |
| - | [[Category: Fernandes, C | + | [[Category: Fernandes, C]] |
| - | [[Category: Graham, S L | + | [[Category: Graham, S L]] |
| - | [[Category: Hamilton, K A | + | [[Category: Hamilton, K A]] |
| - | [[Category: Huber, H E | + | [[Category: Huber, H E]] |
| - | [[Category: Kohl, N E | + | [[Category: Kohl, N E]] |
| - | [[Category: Lobell, R B | + | [[Category: Lobell, R B]] |
| - | [[Category: MacTough, S C | + | [[Category: MacTough, S C]] |
| - | [[Category: Robinson, R G | + | [[Category: Robinson, R G]] |
| - | [[Category: Shaw, A W | + | [[Category: Shaw, A W]] |
| - | [[Category: Taylor, J S | + | [[Category: Taylor, J S]] |
| - | [[Category: Tsou, N N | + | [[Category: Tsou, N N]] |
| - | [[Category: Walsh, E S | + | [[Category: Walsh, E S]] |
| - | [[Category: DeSolms, S J | + | [[Category: DeSolms, S J]] |
[[Category: Alpha-alpha barrel]] | [[Category: Alpha-alpha barrel]] | ||
[[Category: Caax]] | [[Category: Caax]] | ||
Revision as of 09:57, 25 December 2014
Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a
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Categories: Homo sapiens | Beese, L S | Buser, C A | Ciccarone, T M | Ellis-Hutchings, M | Fernandes, C | Graham, S L | Hamilton, K A | Huber, H E | Kohl, N E | Lobell, R B | MacTough, S C | Robinson, R G | Shaw, A W | Taylor, J S | Tsou, N N | Walsh, E S | DeSolms, S J | Alpha-alpha barrel | Caax | Fpp | Ftase | Inhibitor | Pftase | Ra | Transferase
