2cse
From Proteopedia
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| - | [[Image:2cse.gif|left|200px]] | + | [[Image:2cse.gif|left|200px]] |
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| - | '''Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution''' | + | {{Structure |
| + | |PDB= 2cse |SIZE=350|CAPTION= <scene name='initialview01'>2cse</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CSE is a [ | + | 2CSE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_2 Mammalian orthoreovirus 2] and [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSE OCA]. |
==Reference== | ==Reference== | ||
| - | Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution., Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS, Structure. 2005 Oct;13(10):1545-57. PMID:[http:// | + | Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution., Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS, Structure. 2005 Oct;13(10):1545-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16216585 16216585] |
[[Category: Mammalian orthoreovirus 2]] | [[Category: Mammalian orthoreovirus 2]] | ||
[[Category: Mammalian orthoreovirus 3]] | [[Category: Mammalian orthoreovirus 3]] | ||
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[[Category: reovirus]] | [[Category: reovirus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:19:18 2008'' |
Revision as of 14:19, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution
Overview
Reovirus is a useful model for addressing the molecular basis of membrane penetration by one of the larger nonenveloped animal viruses. We now report the structure of the reovirus virion at approximately 7.0 A resolution as obtained by electron cryomicroscopy and three-dimensional image reconstruction. Several features of the myristoylated outer capsid protein mu1, not seen in a previous X-ray crystal structure of the mu1-sigma3 heterohexamer, are evident in the virion. These features appear to be important for stabilizing the outer capsid, regulating the conformational changes in mu1 that accompany perforation of target membranes, and contributing directly to membrane penetration during cell entry.
About this Structure
2CSE is a Protein complex structure of sequences from Mammalian orthoreovirus 2 and Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.
Reference
Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution., Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS, Structure. 2005 Oct;13(10):1545-57. PMID:16216585
Page seeded by OCA on Thu Mar 20 16:19:18 2008
