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4p9j
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9j RCSB], [http://www.ebi.ac.uk/pdbsum/4p9j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9j RCSB], [http://www.ebi.ac.uk/pdbsum/4p9j PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Lau, K | + | [[Category: Lau, K]] |
| - | [[Category: Petegem, F Van | + | [[Category: Petegem, F Van]] |
[[Category: Calcium]] | [[Category: Calcium]] | ||
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
[[Category: Metal transport]] | [[Category: Metal transport]] | ||
[[Category: Signalling]] | [[Category: Signalling]] | ||
Revision as of 10:40, 25 December 2014
Crystal Structure of rabbit Ryanodine Receptor 1 SPRY2 Domain (1070-1246)
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