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2mfp
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1== | |
| - | + | <StructureSection load='2mfp' size='340' side='right' caption='[[2mfp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canadian_hard_winter_wheat Canadian hard winter wheat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MFP FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l61|2l61]], [[2l62|2l62]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mfp RCSB], [http://www.ebi.ac.uk/pdbsum/2mfp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/EC1_WHEAT EC1_WHEAT]] Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis. | [[http://www.uniprot.org/uniprot/EC1_WHEAT EC1_WHEAT]] Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first cyclic analog of a metallothionein (MT) was prepared and analyzed by UV and (magnetic) circular dichroism spectroscopy, ESI-MS as well as NMR spectroscopy. Results reveal that the evaluated cyclic g-Ec-1 domain of the wheat MT Ec-1 retains its ability to coordinate two Zn(II) or Cd(II) ions and adopts a three-dimensional structure that is highly similar to the one of the linear wild-type form. However, the reduced flexibility of the protein backbone facilitates structure solution significantly and results in a certain stabilization of metal binding to the protein. | ||
| - | + | Solution Structure of the Circular gamma-Domain Analog from the Wheat Metallothionein Ec-1.,Tarasava K, Johannsen S, Freisinger E Molecules. 2013 Nov 21;18(11):14414-29. doi: 10.3390/molecules181114414. PMID:24284492<ref>PMID:24284492</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Canadian hard winter wheat]] | [[Category: Canadian hard winter wheat]] | ||
| - | [[Category: Freisinger, E | + | [[Category: Freisinger, E]] |
| - | [[Category: Johannsen, S | + | [[Category: Johannsen, S]] |
| - | [[Category: Tarasava, K | + | [[Category: Tarasava, K]] |
[[Category: Backbone cyclized protein]] | [[Category: Backbone cyclized protein]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Metal-thiolate cluster]] | [[Category: Metal-thiolate cluster]] | ||
[[Category: Metallothionein]] | [[Category: Metallothionein]] | ||
Revision as of 10:41, 25 December 2014
Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1
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