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2xh1
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xh1' size='340' side='right' caption='[[2xh1]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2xh1' size='340' side='right' caption='[[2xh1]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH1 OCA]. <br> | + | <table><tr><td colspan='2'>[[2xh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XH1 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BF5:(3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE'>BF5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BF5:(3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE'>BF5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vgz|2vgz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vgz|2vgz]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xh1 PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 25: | ||
Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement.,Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, Okuwaki K, Ono S, Kajii Y, Rizzi M J Med Chem. 2010 Aug 12;53(15):5684-9. PMID:20684605<ref>PMID:20684605</ref> | Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement.,Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, Okuwaki K, Ono S, Kajii Y, Rizzi M J Med Chem. 2010 Aug 12;53(15):5684-9. PMID:20684605<ref>PMID:20684605</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 31: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Casazza, V | + | [[Category: Casazza, V]] |
| - | [[Category: Garavaglia, S | + | [[Category: Garavaglia, S]] |
| - | [[Category: Kajii, Y | + | [[Category: Kajii, Y]] |
| - | [[Category: Kojima, S I | + | [[Category: Kojima, S I]] |
| - | [[Category: Okuwaki, K | + | [[Category: Okuwaki, K]] |
| - | [[Category: Ono, S I | + | [[Category: Ono, S I]] |
| - | [[Category: Rizzi, M | + | [[Category: Rizzi, M]] |
| - | [[Category: Rossi, F | + | [[Category: Rossi, F]] |
| - | [[Category: Sathyasaikumar, K V | + | [[Category: Sathyasaikumar, K V]] |
| - | [[Category: Schwarcz, R | + | [[Category: Schwarcz, R]] |
[[Category: Covalent inhibition]] | [[Category: Covalent inhibition]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 10:46, 25 December 2014
CRYSTAL STRUCTURE OF HUMAN KAT II-INHIBITOR COMPLEX
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Categories: Human | Casazza, V | Garavaglia, S | Kajii, Y | Kojima, S I | Okuwaki, K | Ono, S I | Rizzi, M | Rossi, F | Sathyasaikumar, K V | Schwarcz, R | Covalent inhibition | Transferase
