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4m7l
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M7L FirstGlance]. <br> | <table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M7L FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [http://www.ebi.ac.uk/pdbsum/4m7l PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [http://www.ebi.ac.uk/pdbsum/4m7l PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Gilliland, G L | + | [[Category: Gilliland, G L]] |
| - | [[Category: Malia, T | + | [[Category: Malia, T]] |
| - | [[Category: Obmolova, G | + | [[Category: Obmolova, G]] |
| - | [[Category: Teplyakov, A | + | [[Category: Teplyakov, A]] |
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Blood clotting-immune system complex]] | [[Category: Blood clotting-immune system complex]] | ||
Revision as of 11:12, 25 December 2014
Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
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