3v2y

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[[Image:3v2y.png|left|200px]]
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==Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A==
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<StructureSection load='3v2y' size='340' side='right' caption='[[3v2y]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v2w|3v2w]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHEDG1, EDG1, S1PR1, S1PR1_HUMAN,E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v2y RCSB], [http://www.ebi.ac.uk/pdbsum/3v2y PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN]] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and maturation by activating G protein-coupled sphingosine 1-phosphate receptors. Here, we present the crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme (S1P(1)-T4L) in complex with an antagonist sphingolipid mimic. Extracellular access to the binding pocket is occluded by the amino terminus and extracellular loops of the receptor. Access is gained by ligands entering laterally between helices I and VII within the transmembrane region of the receptor. This structure, along with mutagenesis, agonist structure-activity relationship data, and modeling, provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P(1), resulting in the modulation of immune and stromal cell responses.
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{{STRUCTURE_3v2y| PDB=3v2y | SCENE= }}
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Crystal structure of a lipid G protein-coupled receptor.,Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC Science. 2012 Feb 17;335(6070):851-5. PMID:22344443<ref>PMID:22344443</ref>
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===Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22344443}}
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==About this Structure==
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[[3v2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2Y OCA].
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==See Also==
==See Also==
*[[G protein-coupled receptor|G protein-coupled receptor]]
*[[G protein-coupled receptor|G protein-coupled receptor]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:022344443</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: Cahalan, S M.]]
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[[Category: Cahalan, S M]]
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[[Category: Clemons, B.]]
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[[Category: Clemons, B]]
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[[Category: Desale, H.]]
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[[Category: Desale, H]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Griffith, M T.]]
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[[Category: Griffith, M T]]
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[[Category: Han, G W.]]
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[[Category: Han, G W]]
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[[Category: Hanson, M A.]]
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[[Category: Hanson, M A]]
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[[Category: Jo, E.]]
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[[Category: Jo, E]]
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[[Category: Kuhn, P.]]
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[[Category: Kuhn, P]]
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[[Category: Reinhart, G.]]
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[[Category: Reinhart, G]]
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[[Category: Rosen, H.]]
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[[Category: Rosen, H]]
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[[Category: Roth, C B.]]
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[[Category: Roth, C B]]
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[[Category: Sanna, M G.]]
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[[Category: Sanna, M G]]
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[[Category: Schuerer, S C.]]
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[[Category: Schuerer, S C]]
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[[Category: Scott, F L.]]
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[[Category: Scott, F L]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens, R C]]
[[Category: Autoimmunity]]
[[Category: Autoimmunity]]
[[Category: Edg receptor]]
[[Category: Edg receptor]]

Revision as of 11:30, 25 December 2014

Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A

3v2y, resolution 2.80Å

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