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3l5h
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l5h RCSB], [http://www.ebi.ac.uk/pdbsum/3l5h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l5h RCSB], [http://www.ebi.ac.uk/pdbsum/3l5h PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN]] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 11:47, 25 December 2014
Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes
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Categories: Homo sapiens | Garrett, T P.J | Xu, Y | Zhang, J G | Cell membrane | Disulfide bond | Fniii | Glycoprotein | Ig-like | Immune system | Immunoglobulin domain | Membrane | Phosphoprotein | Receptor | Secreted | Transmembrane
