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1nnk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1nnk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NNK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1nnk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NNK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE2:3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE'>CE2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE2:3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE'>CE2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftk|1ftk]], [[1fto|1fto]], [[1fw0|1fw0]], [[1ftl|1ftl]], [[1gr2|1gr2]], [[1lb8|1lb8]], [[1lb9|1lb9]], [[1lbc|1lbc]], [[1m5e|1m5e]], [[1m5c|1m5c]], [[1m5b|1m5b]], [[1m5f|1m5f]], [[1mm7|1mm7]], [[1mm6|1mm6]], [[1lbb|1lbb]], [[1my4|1my4]], [[1my3|1my3]], [[1m5d|1m5d]], [[1ftm|1ftm]], [[1nnp|1nnp]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftk|1ftk]], [[1fto|1fto]], [[1fw0|1fw0]], [[1ftl|1ftl]], [[1gr2|1gr2]], [[1lb8|1lb8]], [[1lb9|1lb9]], [[1lbc|1lbc]], [[1m5e|1m5e]], [[1m5c|1m5c]], [[1m5b|1m5b]], [[1m5f|1m5f]], [[1mm7|1mm7]], [[1mm6|1mm6]], [[1lbb|1lbb]], [[1my4|1my4]], [[1my3|1my3]], [[1m5d|1m5d]], [[1ftm|1ftm]], [[1nnp|1nnp]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nnk RCSB], [http://www.ebi.ac.uk/pdbsum/1nnk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nnk RCSB], [http://www.ebi.ac.uk/pdbsum/1nnk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Egebjerg, J | + | [[Category: Egebjerg, J]] |
| - | [[Category: Gouaux, E | + | [[Category: Gouaux, E]] |
| - | [[Category: Hogner, A | + | [[Category: Hogner, A]] |
| - | [[Category: Kastrup, J S | + | [[Category: Kastrup, J S]] |
| - | [[Category: Lunn, M L | + | [[Category: Lunn, M L]] |
| - | [[Category: Stensbol, T B | + | [[Category: Stensbol, T B]] |
[[Category: Agonist complex]] | [[Category: Agonist complex]] | ||
[[Category: Ionotropic glutamate receptor glur2]] | [[Category: Ionotropic glutamate receptor glur2]] | ||
[[Category: Ligand-binding core]] | [[Category: Ligand-binding core]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 12:16, 25 December 2014
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.
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