This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4igm
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='4igm' size='340' side='right' caption='[[4igm]], [[Resolution|resolution]] 2.39Å' scene=''> | <StructureSection load='4igm' size='340' side='right' caption='[[4igm]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4igm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGM OCA]. <br> | + | <table><tr><td colspan='2'>[[4igm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGM FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminocarboxymuconate-semialdehyde_decarboxylase Aminocarboxymuconate-semialdehyde decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.45 4.1.1.45] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igm RCSB], [http://www.ebi.ac.uk/pdbsum/4igm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igm RCSB], [http://www.ebi.ac.uk/pdbsum/4igm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACMSD_HUMAN ACMSD_HUMAN]] Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.<ref>PMID:19843166</ref> <ref>PMID:12140278</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 12: | Line 14: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Aminocarboxymuconate-semialdehyde decarboxylase]] | [[Category: Aminocarboxymuconate-semialdehyde decarboxylase]] | ||
| - | [[Category: Liu, A | + | [[Category: Liu, A]] |
| - | [[Category: Liu, F | + | [[Category: Liu, F]] |
[[Category: Kynurenine pathway]] | [[Category: Kynurenine pathway]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
Revision as of 12:20, 25 December 2014
2.39 Angstrom X-ray Crystal structure of human ACMSD
| |||||||||||
