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4nac

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{{STRUCTURE_4nac| PDB=4nac | SCENE= }}
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==Crystal Structure of the N-terminal Domain of p15RS==
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===Crystal Structure of the N-terminal Domain of p15RS===
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<StructureSection load='4nac' size='340' side='right' caption='[[4nac]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4nac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nad|4nad]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P15RS, RPRD1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nac RCSB], [http://www.ebi.ac.uk/pdbsum/4nac PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>
[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>
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== References ==
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==About this Structure==
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<references/>
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[[4nac]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Human]]
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<references group="xtra"/><references/>
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[[Category: Jin, Z]]
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[[Category: Jin, Z.]]
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[[Category: Mei, K]]
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[[Category: Mei, K.]]
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[[Category: Ren, F]]
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[[Category: Ren, F.]]
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[[Category: Wang, Y]]
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[[Category: Wang, Y.]]
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[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 12:31, 25 December 2014

Crystal Structure of the N-terminal Domain of p15RS

4nac, resolution 2.00Å

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