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3qul
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4S)== | |
| - | + | <StructureSection load='3qul' size='340' side='right' caption='[[3qul]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qul]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3quk|3quk]]</td></tr> | |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qul RCSB], [http://www.ebi.ac.uk/pdbsum/3qul PDBsum]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3qul]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUL OCA]. | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
*[[Major histocompatibility complex|Major histocompatibility complex]] | *[[Major histocompatibility complex|Major histocompatibility complex]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Achour, A | + | [[Category: Achour, A]] |
| - | [[Category: Allerbring, E | + | [[Category: Allerbring, E]] |
| - | [[Category: Duru, A D | + | [[Category: Duru, A D]] |
| - | [[Category: Friemann, R | + | [[Category: Friemann, R]] |
| - | [[Category: Grimm, S | + | [[Category: Grimm, S]] |
| - | [[Category: Madhurantakam, C | + | [[Category: Madhurantakam, C]] |
| - | [[Category: Mazumdar, P A | + | [[Category: Mazumdar, P A]] |
| - | [[Category: Nygren, P | + | [[Category: Nygren, P]] |
[[Category: Sandalova, T]] | [[Category: Sandalova, T]] | ||
| - | [[Category: Spetz, A | + | [[Category: Spetz, A]] |
| - | [[Category: Tomek, M B | + | [[Category: Tomek, M B]] |
| - | [[Category: Uchtenhagen, H | + | [[Category: Uchtenhagen, H]] |
| - | [[Category: Uhlin, M | + | [[Category: Uhlin, M]] |
[[Category: Beta2-microglobulin]] | [[Category: Beta2-microglobulin]] | ||
[[Category: Cell surface]] | [[Category: Cell surface]] | ||
Revision as of 12:37, 25 December 2014
Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4S)
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Categories: Mus musculus | Achour, A | Allerbring, E | Duru, A D | Friemann, R | Grimm, S | Madhurantakam, C | Mazumdar, P A | Nygren, P | Sandalova, T | Spetz, A | Tomek, M B | Uchtenhagen, H | Uhlin, M | Beta2-microglobulin | Cell surface | Immune system | Lcmv | Murine mhc | Receptor binding | T cell receptor | T cell recognition
